ADAM8 enhances osteoclast precursor fusion and osteoclast formation in vitro and in vivo
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چکیده
منابع مشابه
ADAM8 Enhances Osteoclast Precursor Fusion and Osteoclast Formation In Vitro and In Vivo
ADAM8 expression is increased in the interface tissue around a loosened hip prosthesis and in the pannus and synovium of patients with rheumatoid arthritis, but its potential role in these processes is unclear. ADAM8 stimulates osteoclast (OCL) formation, but the effects of overexpression or loss of expression of ADAM8 in vivo and the mechanisms responsible for the effects of ADAM8 on osteoclas...
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Tumor necrosis factor- α (TNF- α ) is a cytokine produced by monocytes, macrophages, and T cells and is induced by pathogens, endotoxins, or related substances. TNF- α may play a key role in bone metabolism and is important in inflammatory bone diseases such as rheumatoid arthritis. Cells directly involved in osteoclastogenesis include macrophages, which are osteoclast precursor cells, osteobla...
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Chapter 5. Osteoclast fusion and fission
Osteoclasts are specialized multinucleated cells with the unique capacity to resorb bone. Despite insight in the various steps of the interaction of osteoclast precursors leading to osteoclast formation, surprisingly little is known about what happens with the multinucleated cell itself after it has been formed. Is fusion limited to the short period of its formation or have osteoclasts the capa...
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ژورنال
عنوان ژورنال: Journal of Bone and Mineral Research
سال: 2010
ISSN: 0884-0431
DOI: 10.1002/jbmr.199